Abstract
The role of lysine-vasopressin and oxytocin, as well as of their analog and fragment (DGAVP, desglycinamide arginine vasopressin; PLG, proiyl-leucyl-glycyl-amine), microinjected into the ventral hippocampus, in the formation and extinction of active avoidance conditioned reflex, was investigated. It was established that the introduction of lysine-vasopressin, as well as of its analog, into the hippocampus promoted the improvement of the formation of the avoidance reaction, while an inhibitory effect was elicited in the period of extinction of the skill. The opposite effects on the active avoidance reaction were obtained with oxytocin and its fragments. It is hypothesized that the observed behavioral changes in the active avoidance reaction are associated with the influence of these peptides on the processes of learning and memory.
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G. G. Gasanov, G. Telegdi, R. Sh. Ibragimov, and T. Kadar, “The influence of the neurohypophyseal peptides on the formation of a conditioned alimentary reflex in rats,” Zh. Vyssh. Nervn. Deyat.,36, No. 5, 905–912 (1986).
B. Bohus, W. H. Gipsen, and D. de Wied, “The effect of lysine vasopressin and ACTH4−10 on conditioned avoidance behavior of hypophysectomized rats,” Neuroendocrinology,11, No. 1, 137–143 (1973).
R. E. Brinton, J. K. Walmsley, K. W. Gee, Y. P. Wan, and H. I. Yamamura, “(3H) Oxytocin binding sites in the rat brain demonstrated by quantitative light microscopic autoradiography,” Eur. J. Pharmacol.,102, No. 2, 365–367 (1984).
R. M. Buijs, “Intra- and extrahypothalamic vasopressin and oxytocin in the rat. Pathways to the limbic system, medulla oblongata and spinal cord,” Cell Tiss. Res.,192, No. 4, 423–435 (1978).
A. Ettenberg, D. Van der Kay, M. Le Moal, G. F. Koob, and F. E. Bloom, “Can aversive properties of (peripherallyinjected) vasopressin account for its putative role in memory?,” Behav. Brain Res.,7, No. 3, 331–350 (1983).
D. M. Gibbs, “Dissociation of oxytocin, vasopressin and corticotropin secretion during different types of stress,” Life Sci.,35, No. 5, 487–491 (1984).
R. Sh. Ibragimov, “Participation of oxytocin injected into limbic brain formations in the process of intravenous heroin self-injection in rats,” Neuroscience, Suppl., 510 (1987).
G. L. Kovaes, B. Bohus, D. H. G. Versteeg, E. R. de Kloet, and D. de Wied, “Effect of oxytocin and vasopressin on memory consolidation: sites of action and catecholaminergic correlates after local microinjection into limbic-midbrain structures,” Brain Res.,175, No. 1, 303–314 (1979).
W. B. J. Mens, M. A. van Egmond, A. A. de Rotte, and Tj. B. van Wimersma Greidanus, “Neurohypophyseal peptide levels in CSF and plasma during passive avoidance behavior in rats,” Norm. Behav.,16, No. 2, 7–13 (1982).
L. J. Pellegrino, A. S. Pellegrino, and A. J. Goshman, in: Stereotaxic Atlas of the Rat Brain, Plenum Press, New York, London (1980).
S. J. Sara, J. Barnett, and P. Toussaint, “Vasopressin accelerates appetitive discrimination learning and impairs its reversal,” Behav. Proc.,7, No. 1, 157–167 (1982).
D. de Wied, “Effects of peptide hormones on behavior,” in: Frontiers in Neuroendocrinology, Eds. W. F. Canong and L. Martini, New York (1969), pp. 97–140.
D. de Wied, “Peptides and behavior,” Life Sci.,20, No. 2, 195–204 (1977).
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Translated from Fizologicheskii Zhurnal SSSR imeni I. M. Sechenova, Vol. 75, No. 1, pp. 8–12, January, 1989.
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Ibragimov, R.S. Influence of neurohypophyseal peptides on the formation of active avoidance conditioned reflex behavior. Neurosci Behav Physiol 20, 189–193 (1990). https://doi.org/10.1007/BF01195453
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DOI: https://doi.org/10.1007/BF01195453