Regular ArticleTenascin-C Inhibits Oligodendrocyte Precursor Cell Migration by both Adhesion-Dependent and Adhesion-Independent Mechanisms
References (0)
Cited by (88)
Migration of myelin-forming cells in the CNS
2020, Cellular Migration and Formation of Axons and Dendrites: Comprehensive Developmental NeuroscienceTenascin-C in the matrisome of neural stem and progenitor cells
2017, Molecular and Cellular NeuroscienceCitation Excerpt :From the sites of birth, OPCs have to migrate long distances towards the territories where myelination of axonal connections will occur (Bergles and Richardson, 2016; Nave, 2010; Nave and Werner, 2014). In vitro, Tnc protein displays anti-adhesive properties and inhibits OPC migration in several cell migration assays (Frost et al., 1996; Kakinuma et al., 2004; Kiernan et al., 1996). Despite these cell biological effects, no substantial deficits in myelin formation could be observed in the Tnc-knockout CNS (Kiernan et al., 1999).
Inhibitors of myelination: ECM changes, CSPGs and PTPs
2014, Experimental NeurologyMigration of myelin-forming cells in the CNS
2013, Cellular Migration and Formation of Neuronal Connections: Comprehensive Developmental NeuroscienceMigration of Myelin-Forming Cells in the CNS
2013, Cellular Migration and Formation of Neuronal ConnectionsAbnormalities of the optic disc
2011, Handbook of Clinical NeurologyCitation Excerpt :Myelination by oligodendrocytes starts centrally and reaches the lamina cribrosa at term or shortly after birth. Oligodendrocytes do not migrate anteriorly to the lamina cribrosa as a consequence of a biochemical barrier, not the mechanics of the lamina cribrosa (Kiernan et al., 1996). The optic nerve, consisting of RGC axons myelinated by oligodendrocytes, is a part of the CNS.
- 1
To whom correspondence should be addressed. Fax: 01223 334089; E-mail: [email protected].