Short CommunicationDCAMKL1, a Brain-Specific Transmembrane Protein on 13q12.3 That Is Similar to Doublecortin (DCX)
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Cited by (56)
Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing
2020, Cell Chemical BiologyCitation Excerpt :Doublecortin-like kinase 1 (DCLK1) is a multi-domain protein belonging to both the doublecortin (DCX) and the protein kinase super families (Reiner et al., 2006). DCLK1 was originally identified in post-mitotic neurons as a regulator of microtubule polymerization in migrating neurons (Koizumi et al., 2017; Lin et al., 2000; Lipka et al., 2016; Qu et al., 2014; Sossey-Alaoui and Srivastava, 1999). Subsequent work established roles for DCLK1 in neuronal migration, neurogenesis, retrograde transport, and neuronal apoptosis (Liu et al., 2012; Mizuguchi et al., 1999; Verissimo et al., 2010).
Doublecortin-like kinase 1 compromises DNA repair and induces chromosomal instability
2018, Biochemistry and Biophysics ReportsDoublecortin-like kinase 1 is a novel biomarker for prognosis and regulates growth and metastasis in basal-like breast cancer
2017, Biomedicine and PharmacotherapyCitation Excerpt :Doublecortin like kinase 1 (DCLK1), locates on chromosome 13q13-q14.1, is a microtubule-associated protein with C-terminal serine/threonine kinase domain [11]. DCLK1 was originally identified in the brain as a MAP based on the high amino acid sequence homology of its N-terminal domains with doublecortin, a protein that plays a crucial role in regulating microtubule dynamics during neurogenesis [12,13]. Recently, DCLK1 has been suggested to serve as the marker of progenitor cell and stem cell [14,15].
Spatiotemporal development of the embryonic nervous system of saccoglossus kowalevskii
2014, Developmental BiologyCitation Excerpt :At present there is no consensus for referring to the Etr/Bruno/CELF family members and the nomenclature used herein is the BrunoA/B nomenclature as per Kerner et al., 2011 (see Supplementary Table S1). Doublecortin-like kinase (DCLK) belongs to the Doublecortin (DCX) family of proteins, is associated with microtubules from brain extracts and expressed in migrating immature neurons (often referred to as neuroblasts) of the cortex (Burgess and Reiner 2000; Koizumi et al. 2006; Sossey-Alaoui and Srivastava 1999). Surprisingly elav is expressed ubiquitously, albeit weakly, in the ectoderm at mid-blastula stage (16 hpf) and is upregulated in the ectoderm at the onset of gastrulation, 21–22 hpf (Figs. 1B and 3B).
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