Regular ArticleMechanisms of Motor Recovery after Subtotal Spinal Cord Injury: Insights from the Study of Mice Carrying a Mutation (WldS) That Delays Cellular Responses to Injury☆
References (61)
- et al.
Modeling of acute spinal cord injury in the rat: neuroprotection and enhanced recovery with methylprednisolone, U-74006F and YM-14673
Exp. Neurol.
(1994) Morphometric analysis of blood vessels in chronic experimental spinal cord injury: Hypervascularity and recovery of function
J. Neurol. Sci.
(1991)- et al.
A mechanism for the observed recovery from ineffectiveness of synapses in the central nervous system
J. Theor. Biol.
(1978) - et al.
Recovery of locomotor function after hemisection of the spinal cord in cats
Brain Res. Bull.
(1986) - et al.
Relationship between residual hindlimb-assisted locomotion and surviving axons after incomplete spinal cord injuries
Exp. Neurol.
(1977) - et al.
Delayed macrophage responses and myelin clearance during Wallerian degeneration in the central nervous system: the dorsal radiculotomy model
Exp. Neurol.
(1994) - et al.
Lack of sprouting and its presence after lesions of the cat spinal cord
Brain Res.
(1982) - et al.
Demonstration of functionally ineffective synapses in the guinea pig spinal cord
Exp. Neurol.
(1977) - et al.
Chronic hypoxia causes morphological alterations in astroglia in the phrenic nucleus of young adult rats
Exp. Neurol.
(1990) - et al.
Macrophage responses and myelin clearance during Wallerian degeneration: relevance to immune-mediated demyelination
J. Neuroimmunol.
(1992)
Functional plasticity in the respiratory pathway of the mammalian spinal cord
Exp. Neurol.
Spinal cord injury in the rat: Treatment with bacterial lipopolysaccharide and indomethacin enhances cellular repair and locomotor function
Exp. Neurol.
Spared descending pathways mediate locomotor recovery after subtotal spinal cord injury
Neurosci. Lett.
Recovery of postural control following chronic bilateral hemisections at different spinal cord levels in adult cats
Exp. Neurol.
Origin of the connective tissue scar in the transected rat spinal cord
Exp. Neurol.
Recovery of locomotion after spinal cord hemisection: An X-ray study of the cat hindlimb
Exp. Neurol.
Recovery of function after spinal cord hemisection in newborn and adult rats: Differential effects on reflex and locomotor function
Exp. Neurol.
Delayed wallerian degeneration in the central nervous system of Ola mice: An ultrastructural study
J. Neurol. Sci.
A quantitative spatial analysis of the blood-spinal cord barrier. I. Permeability changes after experimental contusion injury
Exp. Neurol.
The recovery of 5-HT immunoreactivity in lumbosacral spinal cord and locomotor function after thoracic hemisection
Exp. Neurol.
Prostaglandins modulate alterations of microvascular permeability, blood flow, edema and serotonin levels following spinal cord injury: an experimental study in the rat
Neuroscience
Signals that induce sprouting in the central nervous system: Sprouting is delayed in strain of mouse exhibiting delayed axonal degeneration
Exp. Neurol.
Retarded Wallerian degeneration following peripheral nerve transection in C57BL/6/Ola mice is associated with delayed down-regulation of the P0 gene
Brain Res.
Enhancement of action potential conduction following demyelination: Experimental approaches to restoration of function in multiple sclerosis and spinal cord injury
Prog. Brain Res.
Retrograde messengers and long-term potentiation: A progress report
J. Lipid Mediat. Cell Signal.
Spinal cord contusion in the rat: production of graded, reproducible, injury groups
Exp. Neurol.
Experimental analysis of progressive necrosis after spinal cord trauma in the rat: The etiologic role of inflammatory responses
Exp. Neurol.
Efficient conversion of nonparametric information into a metric system
The Quantitative Analysis of Social Problems
Effects of treatment with U-74006F on neurological outcome following experimental spinal cord injury
J. Neurosurg.
Effects of timing of methylprednisolone or naloxone administration on recovery of segmental and long-tract neurological function in NASCIS 2
J. Neurosurg.
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Motor-evoked potentials in the intraoperative decision-making of circumferential decompression via posterior approach for treating thoracic posterior longitudinal ligament ossification
2021, Spine JournalCitation Excerpt :All of these findings may suggest that when the patients have experienced severe ischemic spinal cord injury after PD, further ventral decompression may not only be unable to reverse this injury but also aggravate ischemia, leading to more serious spinal cord injury. In contrast, in the patients without obvious spinal cord ischemia during PD, although ventral decompression may not further recover the impulse transmission within the spinal cord, adequate decompression of the spinal cord may promote plastic processes within the spinal cord below the injury site and “extraspinal” complementary mechanisms (two main mechanisms for the functional recoveries in patients with no MEP changes) [22–24], resulting in relatively good clinical outcomes. In addition, although MEP improvement after PD also suggested that the spinal cord can tolerate further ischemia during ventral decompression, a similar clinical prognosis between the CD and PD groups supported that further anterior decompression may not achieve a better prognosis if spinal cord function has recovered significantly after PD.
Sprouting of axonal collaterals after spinal cord injury is prevented by delayed axonal degeneration
2014, Experimental NeurologyCitation Excerpt :This suggests that any therapy focused on the enhancement of collateral sprouting must be focalized on specific axonal tracts (i.e. motor tracts) to avoid the adverse side effects of the sensory sprouting after a spinal trauma. By using the BMS rating scale to assess general locomotion and the grid walk, for skilled locomotion aspects, we showed a diminished locomotor recovery in Wlds mice, in agreement with a previous report (Zhang et al., 1998). Using a more specific assessment of individual locomotor parameters, we found that in the WldS mice, the locomotor recovery does not reach the levels of the WT strain, even though axons eventually degenerate (Fig. 4B).
Blockage of lysophosphatidic acid signaling improves spinal cord injury outcomes
2012, American Journal of PathologySmall mammal MRI imaging in spinal cord injury: A novel practical technique for using a 1.5 T MRI
2008, Journal of Neuroscience MethodsGenetic approaches to autonomic dysreflexia
2006, Progress in Brain ResearchCitation Excerpt :While the genetic lesion accounting for the Wlds mutation has been identified as a fusion of the N-terminal portion of the ubiquitination factor E4B (Ube4b) to the nicotinamide mononucleotide adenylyltransferase (Nmnat) gene, the mechanism through which this mutation results in delayed Wallerian degeneration is unclear (Mack et al., 2001). Wlds mice have previously been utilized to demonstrate the importance of Wallerian degeneration as a trigger for the plasticity involved in locomotor recovery after spinal cord injury in mice (Zhang et al., 1998). The clip-compression injury model in the mouse has been previously described (Joshi and Fehlings, 2002a, b).
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E. R. Tufte