Table 1.

Significant regions identified by fMRI in the analyses of Figures 3, 4, and 5 (all p < 0.05, corrected for multiple comparisons)

	MNI–X	MNI–Y	MNI–Z	No. voxels	t value	p value	BA
Contrast: main effect of task, tolcapone versus placebo (Fig. 3)
Area–Pos.
L fus gyrus	−30	−87	−12	286	7.24	6.7 × 10⁻⁷	18
L prec gyrus	−42	−3	48	233	6.51	0.000002	6
Midbrain	0	−30	−6	224	6.62	0.000001	—
R prec gyrus	39	−3	51	68	4.74	0.0001	6
L SMA	−3	6	54	54	4.43	0.0002	6
Area–Neg.
B SFG	0	30	57	519	−6.46	0.000002	8
R MFG	42	54	−12	343	−5.19	0.00003	11
L MOG	−21	−81	3	143	−5.52	0.00002	17
L SFG	−36	54	−15	140	−5.42	0.00002	11
L STG	−57	0	3	128	−4.50	0.0002	22
R IPL	45	−60	57	112	−4.23	0.0003	40
L SPL	−27	−45	72	92	−4.36	0.0003	5
L IPL	−42	−54	60	80	−4.10	0.0005	40
L SMG	−66	−24	24	65	−3.94	0.0007	2
R ITG	63	−33	−18	38	−5.21	0.00003	20
Contrast: correlation, Want (tolcapone–placebo) with ICR (tolcapone–placebo) (Fig. 4)
Area–Neg.
L ant insula	−42	18	−6	64	−4.92	0.00007	47
L postc gyrus	−39	−27	66	36	−4.72	0.0001	3
L putamen	−24	3	−9	30	−3.55	0.002	—
Contrast: Want Later–Want Now (Fig. 5a)
Area–Pos.
L ant insula	−30	21	−6	62	5.84	0.00002	47
R mid cing	3	27	39	51	4.23	0.0006	32
Area–Neg.
R postc gyrus	51	−9	36	38	−4.68	0.0002	6
Contrast: resting state, striatal seed, tolcapone–placebo (Fig. 5b)
Area–Pos.
L pgACC	−6	36	6	14	−4.18	0.0004	24

The t statistics and associated probability values, as well as approximate Brodmann areas (BAs) estimated by the Talairach Daemon (http://www.talairach.org/daemon.html), are displayed for the peak voxel within each cluster. Abbreviations: cing, cingulate; fus, fusiform; prec, precentral; postc, postcentral; pgACC, pregenual anterior cingulate cortex; IPL, inferior parietal lobule; ITG, inferior temporal gyrus; MFG, middle frontal gyrus; MOG, middle occipital gyrus; SFG, superior frontal gyrus; SMA, supplementary motor area; SMG, supramarginal gyrus; SPL, superior parietal lobule; STG, superior temporal gyrus.