Table 2.

SNPs whose associations with FA reach overall significance, at levels that correct for the genome-wide search, and correct for the number of ROIs assessed

SNPROIs (β, P)aChromosome (position in base pairs)Name of gene containing the SNPb
rs124100076 (0.03, 3.0 × 10−8)1 (15136857)KAZN
9 (0.03, 1.0 × 10−8)
rs1272568612 (0.09, 2.0 × 10−11)1 (15481005)FHAD1
13 (0.07, 9.0 × 10−10)
rs85088011 (−0.02, 9.0 × 10−8)2 (185913434)
15 (−0.02, 6.0 × 10−8)
rs1309729712 (0.05, 8.0 × 10−8)3 (29150402)
13 (0.04, 2.0 × 10−8)
rs1703828913 (0.06, 1.0 × 10−8)4 (109131688)HADH
rs69156458 (−0.01, 6.0 × 10−10)6 (143882733)
rs271023413 (0.03, 2.0 × 10−8)7 (152432764)
rs1009146012 (0.09, 1.0 × 10−9)8 (24590168)
13 (0.09, 2.0 × 10−11)
rs1008835912 (0.09, 8.0 × 10−10)8 (24592338)
13 (0.09, 1.0 × 10−11)
rs1113581612 (0.09, 8.0 × 10−10)8 (24603960)
13 (0.09, 1.0 × 10−11)
rs1268098213 (0.05, 3.0 × 10−8)8 (24680599)
r487226213 (0.05, 3.0 × 10−8)8 (24681608)
rs1099061912 (0.04, 1.0 × 10−8)9 (105005484)
13 (0.03, 6.0 × 10−11)
rs1074255212 (0.08, 3.0 × 10−8)11 (5145403)
13 (0.07, 1.0 × 10−8)
rs8971021 (0.02, 8.0 × 10−9)11 (8288070)
rs112380098 (0.02, 4.0 × 10−8)11 (79237030)
rs1089460613 (0.02, 2.0 × 10−8)11 (132176821)OPCML
rs1084493212 (0.05, 2.0 × 10−8)12 (34564711)
rs1182952812 (0.06, 2.0 × 10−9)12 (34669982)
13 (0.05, 2.0 × 10−8)
rs1694654113 (0.03, 8.0 × 10−8)12 (115142545)
rs100998113 (0.07, 2.0 × 10−8)12 (115588318)
rs171260728 (0.02, 2.0 × 10−8)14 (52577434)DDHD1
rs649896412 (0.05, 7.0 × 10−8)16 (63502473)
13 (0.05, 9.0 × 10−9)
rs67815613 (0.04, 6.0 × 10−8)18 (2992436)LPIN2

  • ↵aβ is the partial regression coefficient that represents change in the average FA of the ROI due to the unit additive effect of the major allele of the SNP; p is the significance of β (uncorrected for multiple comparisons).

  • ↵bSee Table 5 for the full name and function of these genes.