Brain clusters showing significant differences between APOE ϵ3 homozygotes and ϵ4 carriers
| Brain network | Contrast | Brain region | Cluster size (voxels) | Peak MNI coordinates (mm) | ||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| Anterior DMN | ϵ3 Homozygotes > ϵ4 carriers | RH frontal pole/anterior cingulate/ medial prefrontal | 1435 | 26 | 46 | 24 |
| LH frontal pole/medial prefrontal | 945 | −30 | 44 | −10 | ||
| Posterior DMN | ϵ3 Homozygotes > ϵ4 carriers | LH posterior cingulate gyrus | 17 | −6 | −48 | 18 |
LH, Left hemisphere; RH, right hemisphere.