Regions | (x, y, z) | Voxels | p Value | |
---|---|---|---|---|
Uncorrected | Corrected | |||
Left superior temporal gyrus/fronto-parietal operculum (BA22) | −37, −40, +9 | 21 | 0.001 | 0.009* |
Right superior temporal gyrus/fronto-parietal operculum (BA22) | +51, −3, +8 | 13 | 0.006 | 0.082 |
Left hippocampus and parahippocampus | −17, −34, −12 | 43 | <0.001 | 0.005* |
Dorsal anterior cingulate (BA32) | −14, +18, +30 | 27 | <0.001 | 0.006* |
Caudal orbital cortex | −13, +24, −16 | 32 | <0.001 | 0.004* |
Pregenual anterior cingulate (BA24)/striatum | −02, +24, +02 | 19 | 0.013 | 0.179 |
Middle temporal cortex (BA20) | +58, −12, −22 | 70 | 0.002 | 0.028* |
Right parahippocampus | +31, −30, −14 | 17 | 0.007 | 0.102 |
Right hippocampus | +19, −19, −6 | 14 | <0.001 | 0.004* |
Medial prefrontal cortex (frontal pole) (BA10) | +16, +53, +18 | 15 | 0.001 | 0.020* |
Inferior orbital cortex (BA11) | +7, +58, −21 | 13 | 0.004 | 0.054 |
Gyrus rectus (BA11) | +4, +23, −21 | 11 | 0.001 | 0.014* |
Hypothalamus | 0, 0, −9 | 15 | 0.012 | 0.168 |
Dorsal occipital cortex (BA19) | 0, −89, +40 | 27 | 0.002 | 0.029* |
Regions were derived from comparisons of a priori areas shown in supplemental Figure 1 (available at www.jneurosci.org as supplemental material) and are shown in Figures 1 and 2. Listed are the Talairach coordinates, voxel number (size), and significance level for each region. p values denote significant differences in connectivity between APOE4+ and APOE4− groups.
↵*Significant at p ≤ 0.05 after Bonferroni correction for multiple comparisons.