Table 1.

Gray matter areas with a positive correlation between intelligence and regional volume

Brain regionSidet valuexyzSize (mm3)
Frontal lobe
    Inf frontal gR5.312965−218462a
5.005141−12
5.2558251
    Middle frontal gL3.11b−3161539
    Sup frontal gL3.10−1860621
    Sup frontal gR4.0075946287c
3.7995812
    Cingulate gR4.03953−5
    Inf frontal gL4.24−4840−16653
3.25−5133−11
3.11b−5530−4
    Inf frontal gL3.19−58221115
    Middle frontal gR3.18451848280
    Precentral gR3.2649−150
3.4744−746
    Inf frontal gL3.58−431582057
3.25−511113
3.74−5694
    Cingulate gL4.57−99313131
4.25−9−2932
3.57−7−1932
    Sup frontal gMid4.31−3−10721332
    Precentral g3.091−2369
    Cingulate gR3.4610−1535274
3.0212−2241
Parietal and temporal lobes
    Postcentral gL3.33−64−92254
    Supramarginal gR5.1950−382626549d
    Middle temporal g4.4150−461
    Supramarginal g4.4451−5542
    Sup temporal gL3.02−47−38111114
3.84−56−4116
    Inf temporal gL3.40−63−58−84839
    Middle temporal gL4.31−61−65−1
4.81−53−684
    Angular gR3.2144−582439
    Angular gL3.08−56−623527
    Angular gL4.18−44−72261069e
Subcortical
    HypothalamusMid3.10−17−16312
3.56−3−3−18
    Cerebellum, lobule VIL3.06b−28−51−2738
  • Significantly correlated (p < 0.05) regions with an extent of more than five voxels are reported, in rostrocaudal order within each lobe. The coordinates in Montreal Neurological Institute (MNI) space and t values of the three most significant peak voxels of each cluster are given. When controlling for age, trends at p = 0.08 were found for all peaks, except for three peaks that were significant at p = 0.09 (see footnote at the respective t value). g, Gyrus; Inf, inferior; Sup, superior; L, left; R, right.

  • aThe cluster extended rostrocaudally from y = 6 in the inferior frontal gyrus to the frontal pole; in its rostral part, it extended dorsally into the right middle and superior frontal gyri and ventromedially into orbitofrontal cortex.

  • bThe peak had a trend for significance at p = 0.09 when controlling for age.

  • cThe cluster extended caudally in the right cingulate gyrus to y = 16.

  • dThe cluster extended dorsoventrally from the postcentral sulcus to the inferior temporal and fusiform gyri, in posterior parietotemporal cortex.

  • eThe cluster extended caudally into the middle occipital gyrus.