Table 1.

Cellular composition of the adult rat brain and its subregions

Cortex Cerebellum Olfactory bulb Remaining areas Total
Estimates CV Estimates CV Estimates CV Estimates CV Estimates CV
Weight (mg) 770 ± 113 0.15 272 ± 38 0.14 77 ± 23 0.30 683 ± 153 0.22 1802 ± 313 0.17
n cells (×106) 76.71 ± 3.02 0.04 168.18 ± 12.57 0.07 20.87 ± 5.80 0.28 65.90 ± 9.64 0.15 331.65 ± 8.84 0.03
Cells (×103)/mg 101.52 ± 17.40 0.17 631.24 ± 128.58 0.20 272.43 ± 33.89 0.12 99.57 ± 23.97 0.24 188.79 ± 36.65 0.19
Percentage of NeuN+ nuclei 40.58 ± 5.34 0.13 82.78 ± 3.24 0.04 53.60 ± 4.28 0.08 28.12 ± 3.14 0.11 60.31 ± 2.35 0.04
n neurons (×106) 31.02 ± 3.03 0.10 139.17 ± 11.19 0.10 11.26 ± 3.68 0.10 18.68 ± 4.24 0.10 200.13 ± 12.17 0.06
Neurons (×103)/mg 41.09 ± 8.00 0.19 522.69 ± 108.85 0.21 146.92 ± 27.50 0.19 27.81 ± 6.17 0.22 113.98 ± 23.16 0.20
n non-neuronal cells (×106) 45.69 ± 5.68 0.12 29.01 ± 6.28 0.08 9.61 ± 2.42 0.33 47.22 ± 5.98 0.23 131.52 ± 6.11 0.05
Percentage of brain weight 42.86 ± 1.74 0.04 15.17 ± 1.00 0.06 4.24 ± 0.77 0.18 37.72 ± 2.55 0.07
Percentage of all cells 23.15 ± 1.23 0.05 50.69 ± 3.16 0.06 6.31 ± 1.83 0.29 19.86 ± 2.74 0.14
Percentage of all neurons 15.48 ± 0.94 0.06 69.57 ± 4.37 0.06 5.64 ± 1.90 0.34 9.31 ± 1.96 0.21
  • Values are mean ± SD. CV = SD/mean. n cells, total number of cells (in millions); Cells (×103)/mg, cell density per milligram of tissue (in thousands); n neurons, total number of neurons (in millions); Neurons (×103)/mg, neuronal density per milligram of tissue (in thousands); n non-neuronal cells, total number of non-neuronal cells (in millions, defined as n cells - n neurons). Large SD and CV values for olfactory bulb weight can be partly explained by the difficulty of dissecting this structure undamaged.