TY - JOUR T1 - Global Connectivity of Prefrontal Cortex Predicts Cognitive Control and Intelligence JF - The Journal of Neuroscience JO - J. Neurosci. SP - 8988 LP - 8999 DO - 10.1523/JNEUROSCI.0536-12.2012 VL - 32 IS - 26 AU - Michael W. Cole AU - Tal Yarkoni AU - Grega Repovš AU - Alan Anticevic AU - Todd S. Braver Y1 - 2012/06/27 UR - http://www.jneurosci.org/content/32/26/8988.abstract N2 - Control of thought and behavior is fundamental to human intelligence. Evidence suggests a frontoparietal brain network implements such cognitive control across diverse contexts. We identify a mechanism—global connectivity—by which components of this network might coordinate control of other networks. A lateral prefrontal cortex (LPFC) region's activity was found to predict performance in a high control demand working memory task and also to exhibit high global connectivity. Critically, global connectivity in this LPFC region, involving connections both within and outside the frontoparietal network, showed a highly selective relationship with individual differences in fluid intelligence. These findings suggest LPFC is a global hub with a brainwide influence that facilitates the ability to implement control processes central to human intelligence. ER -