RT Journal Article SR Electronic T1 Global Connectivity of Prefrontal Cortex Predicts Cognitive Control and Intelligence JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 8988 OP 8999 DO 10.1523/JNEUROSCI.0536-12.2012 VO 32 IS 26 A1 Michael W. Cole A1 Tal Yarkoni A1 Grega Repovš A1 Alan Anticevic A1 Todd S. Braver YR 2012 UL http://www.jneurosci.org/content/32/26/8988.abstract AB Control of thought and behavior is fundamental to human intelligence. Evidence suggests a frontoparietal brain network implements such cognitive control across diverse contexts. We identify a mechanism—global connectivity—by which components of this network might coordinate control of other networks. A lateral prefrontal cortex (LPFC) region's activity was found to predict performance in a high control demand working memory task and also to exhibit high global connectivity. Critically, global connectivity in this LPFC region, involving connections both within and outside the frontoparietal network, showed a highly selective relationship with individual differences in fluid intelligence. These findings suggest LPFC is a global hub with a brainwide influence that facilitates the ability to implement control processes central to human intelligence.