RT Journal Article SR Electronic T1 Sleep Deprivation Biases the Neural Mechanisms Underlying Economic Preferences JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 3712 OP 3718 DO 10.1523/JNEUROSCI.4407-10.2011 VO 31 IS 10 A1 Vinod Venkatraman A1 Scott A. Huettel A1 Lisa Y. M. Chuah A1 John W. Payne A1 Michael W. L. Chee YR 2011 UL http://www.jneurosci.org/content/31/10/3712.abstract AB A single night of sleep deprivation (SD) evoked a strategy shift during risky decision making such that healthy human volunteers moved from defending against losses to seeking increased gains. This change in economic preferences was correlated with the magnitude of an SD-driven increase in ventromedial prefrontal activation as well as by an SD-driven decrease in anterior insula activation during decision making. Analogous changes were observed during receipt of reward outcomes: elevated activation to gains in ventromedial prefrontal cortex and ventral striatum, but attenuated anterior insula activation following losses. Finally, the observed shift in economic preferences was not correlated with change in psychomotor vigilance. These results suggest that a night of total sleep deprivation affects the neural mechanisms underlying economic preferences independent of its effects on vigilant attention.