TY - JOUR T1 - <em>Teashirt 3</em> Regulates Development of Neurons Involved in Both Respiratory Rhythm and Airflow Control JF - The Journal of Neuroscience JO - J. Neurosci. SP - 9465 LP - 9476 DO - 10.1523/JNEUROSCI.1765-10.2010 VL - 30 IS - 28 AU - Xavier Caubit AU - Muriel Thoby-Brisson AU - Nicolas Voituron AU - Pierre Filippi AU - Michelle Bévengut AU - Hervé Faralli AU - Sébastien Zanella AU - Gilles Fortin AU - Gérard Hilaire AU - Laurent Fasano Y1 - 2010/07/14 UR - http://www.jneurosci.org/content/30/28/9465.abstract N2 - Neonatal breathing in mammals involves multiple neuronal circuits, but its genetic basis remains unclear. Mice deficient for the zinc finger protein Teashirt 3 (TSHZ3) fail to breathe and die at birth. Tshz3 is expressed in multiple areas of the brainstem involved in respiration, including the pre-Bötzinger complex (preBötC), the embryonic parafacial respiratory group (e-pF), and cranial motoneurons that control the upper airways. Tshz3 inactivation led to pronounced cell death of motoneurons in the nucleus ambiguus and induced strong alterations of rhythmogenesis in the e-pF oscillator. In contrast, the preBötC oscillator appeared to be unaffected. These deficits result in impaired upper airway function, abnormal central respiratory rhythm generation, and altered responses to pH changes. Thus, a single gene, Tshz3, controls the development of diverse components of the circuitry required for breathing. ER -