TY - JOUR T1 - Grape-Derived Polyphenolics Prevent Aβ Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease JF - The Journal of Neuroscience JO - J. Neurosci. SP - 6388 LP - 6392 DO - 10.1523/JNEUROSCI.0364-08.2008 VL - 28 IS - 25 AU - Jun Wang AU - Lap Ho AU - Wei Zhao AU - Kenjiro Ono AU - Clark Rosensweig AU - Linghong Chen AU - Nelson Humala AU - David B. Teplow AU - Giulio M. Pasinetti Y1 - 2008/06/18 UR - http://www.jneurosci.org/content/28/25/6388.abstract N2 - Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive impairments in memory and cognition. Extracellular accumulation of soluble high-molecular-weight (HMW) Aβ oligomers has been proposed to be largely responsible for AD dementia and memory deficits in the Tg2576 mice, a model of AD. In this study, we found that a naturally derived grape seed polyphenolic extract can significantly inhibit amyloid β-protein aggregation into high-molecular-weight oligomers in vitro. When orally administered to Tg2576 mice, this polyphenolic preparation significantly attenuates AD-type cognitive deterioration coincidentally with reduced HMW soluble oligomeric Aβ in the brain. Our study suggests that grape seed-derived polyphenolics may be useful agents to prevent or treat AD. ER -