@article {Wang6388, author = {Jun Wang and Lap Ho and Wei Zhao and Kenjiro Ono and Clark Rosensweig and Linghong Chen and Nelson Humala and David B. Teplow and Giulio M. Pasinetti}, title = {Grape-Derived Polyphenolics Prevent Aβ Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer{\textquoteright}s Disease}, volume = {28}, number = {25}, pages = {6388--6392}, year = {2008}, doi = {10.1523/JNEUROSCI.0364-08.2008}, publisher = {Society for Neuroscience}, abstract = {Alzheimer{\textquoteright}s disease (AD) is a neurodegenerative disorder characterized by progressive impairments in memory and cognition. Extracellular accumulation of soluble high-molecular-weight (HMW) Aβ oligomers has been proposed to be largely responsible for AD dementia and memory deficits in the Tg2576 mice, a model of AD. In this study, we found that a naturally derived grape seed polyphenolic extract can significantly inhibit amyloid β-protein aggregation into high-molecular-weight oligomers in vitro. When orally administered to Tg2576 mice, this polyphenolic preparation significantly attenuates AD-type cognitive deterioration coincidentally with reduced HMW soluble oligomeric Aβ in the brain. Our study suggests that grape seed-derived polyphenolics may be useful agents to prevent or treat AD.}, issn = {0270-6474}, URL = {https://www.jneurosci.org/content/28/25/6388}, eprint = {https://www.jneurosci.org/content/28/25/6388.full.pdf}, journal = {Journal of Neuroscience} }