PT - JOURNAL ARTICLE AU - Ben Seymour AU - Nathaniel Daw AU - Peter Dayan AU - Tania Singer AU - Ray Dolan TI - Differential Encoding of Losses and Gains in the Human Striatum AID - 10.1523/JNEUROSCI.0400-07.2007 DP - 2007 May 02 TA - The Journal of Neuroscience PG - 4826--4831 VI - 27 IP - 18 4099 - http://www.jneurosci.org/content/27/18/4826.short 4100 - http://www.jneurosci.org/content/27/18/4826.full SO - J. Neurosci.2007 May 02; 27 AB - Studies on human monetary prediction and decision making emphasize the role of the striatum in encoding prediction errors for financial reward. However, less is known about how the brain encodes financial loss. Using Pavlovian conditioning of visual cues to outcomes that simultaneously incorporate the chance of financial reward and loss, we show that striatal activation reflects positively signed prediction errors for both. Furthermore, we show functional segregation within the striatum, with more anterior regions showing relative selectivity for rewards and more posterior regions for losses. These findings mirror the anteroposterior valence-specific gradient reported in rodents and endorse the role of the striatum in aversive motivational learning about financial losses, illustrating functional and anatomical consistencies with primary aversive outcomes such as pain.