TY - JOUR T1 - Tau Protects Microtubules in the Axon from Severing by Katanin JF - The Journal of Neuroscience JO - J. Neurosci. SP - 3120 LP - 3129 DO - 10.1523/JNEUROSCI.5392-05.2006 VL - 26 IS - 12 AU - Liang Qiang AU - Wenqian Yu AU - Athena Andreadis AU - Minhua Luo AU - Peter W. Baas Y1 - 2006/03/22 UR - http://www.jneurosci.org/content/26/12/3120.abstract N2 - Microtubules in the axon are more resistant to severing by katanin than microtubules elsewhere in the neuron. We have hypothesized that this is because of the presence of tau on axonal microtubules. When katanin is overexpressed in fibroblasts, the microtubules are severed into short pieces, but this phenomenon is suppressed by the coexpression of tau. Protection against severing is also afforded by microtubule-associated protein 2 (MAP2), which has a tau-like microtubule-binding domain, but not by MAP1b, which has a different microtubule-binding domain. The microtubule-binding domain of tau is required for the protection, but within itself, provides less protection than the entire molecule. When tau (but not MAP2 or MAP1b) is experimentally depleted from neurons, the microtubules in the axon lose their characteristic resistance to katanin. These results, which validate our hypothesis, also suggest a potential explanation for why axonal microtubules deteriorate in neuropathies involving the dissociation of tau from the microtubules. ER -