PT - JOURNAL ARTICLE AU - Gregory S. Berns AU - Samuel M. McClure AU - Giuseppe Pagnoni AU - P. Read Montague TI - Predictability Modulates Human Brain Response to Reward AID - 10.1523/JNEUROSCI.21-08-02793.2001 DP - 2001 Apr 15 TA - The Journal of Neuroscience PG - 2793--2798 VI - 21 IP - 8 4099 - http://www.jneurosci.org/content/21/8/2793.short 4100 - http://www.jneurosci.org/content/21/8/2793.full SO - J. Neurosci.2001 Apr 15; 21 AB - Certain classes of stimuli, such as food and drugs, are highly effective in activating reward regions. We show in humans that activity in these regions can be modulated by the predictability of the sequenced delivery of two mildly pleasurable stimuli, orally delivered fruit juice and water. Using functional magnetic resonance imaging, the activity for rewarding stimuli in both the nucleus accumbens and medial orbitofrontal cortex was greatest when the stimuli were unpredictable. Moreover, the subjects' stated preference for either juice or water was not directly correlated with activity in reward regions but instead was correlated with activity in sensorimotor cortex. For pleasurable stimuli, these findings suggest that predictability modulates the response of human reward regions, and subjective preference can be dissociated from this response.