Article Information
- Received November 7, 2011
- Accepted December 14, 2011
- First published February 8, 2012.
- Version of record published February 8, 2012.
Author Information
- M. Camila Almeida1,2,
- Tamara Hew-Butler1,
- Renato N. Soriano1,
- Sara Rao3,
- Weiya Wang3,
- Judy Wang3,
- Nuria Tamayo4,
- Daniela L. Oliveira1,
- Tatiane B. Nucci1,
- Prafulla Aryal5,
- Andras Garami1,
- Diana Bautista5,
- Narender R. Gavva3, and
- Andrej A. Romanovsky1
- 1Systemic Inflammation Laboratory (FeverLab), Trauma Research, St. Joseph's Hospital and Medical Center, Phoenix, Arizona 85013,
- 2Natural and Humanities Sciences Center, Federal University of ABC, Santo André, SP 09210-170, Brazil,
- 3Departments of Neuroscience and
- 4Chemistry Research and Discovery, Amgen, Thousand Oaks, California 91320, and
- 5Department of Molecular and Cell Biology, University of California, Berkeley, California 94720
Author contributions
Author contributions: M.C.A., N.T., D.B., N.R.G., and A.A.R. designed research; M.C.A., T.H.-B., R.N.S., S.R., W.W., J.W., N.T., D.L.O., T.B.N., P.A., A.G., and D.B. performed research; M.C.A., T.H.-B., R.N.S., S.R., W.W., J.W., D.L.O., T.B.N., P.A., A.G., D.B., N.R.G., and A.A.R. analyzed data; M.C.A., R.N.S., N.T., D.B., N.R.G., and A.A.R. wrote the paper.
Disclosures
- Received November 7, 2011.
- Accepted December 14, 2011.
This work was supported by study agreements with Amgen (A.A.R.), National Institutes of Health Grants R01NS41233 (A.A.R.) and R01AR059385 (D.B.), and the São Paulo State Research Support Foundation Fellowship 07/50902-0 (R.N.S.). We thank Peter Wettenstein for engineering assistance with the thermogradient studies; Gustavo M. B. Souza for histological assistance; Kenneth D. Wild, James J. J. Treanor, and Mark H. Norman for their support for the antagonist development project; Nancy L. Romanovsky for graphics assistance; and Catherine M. Krall for editing this manuscript. R.N.S. was on leave from the Department of Physiology, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil. A.G. was on leave from the Department of Pathophysiology and Gerontology, Medical School, University of Pécs, Pécs, H-7624, Hungary.
S.R., W.W., J.W., N.T., and N.R.G. are employed by Amgen. A.A.R. has consulted for Amgen and TRP programs at several other pharmaceutical companies, and his TRP-related research has been supported by Amgen and Abbott Laboratories.
- Correspondence should be addressed to Andrej A. Romanovsky, St. Joseph's Hospital, 350 West Thomas Road, Phoenix, AZ 85013. aromano{at}chw.edu
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