Figure 4. MB treatment ameliorates behavioral phenotypes in the R6/2 mouse model of HD. A, Timeline of the study illustrating the age of the mice when treatment commenced and the timing of the behavioral testing (n = 10 per group). B, Treating R6/2 mice (n = 10) results in higher body weight compared to vehicle controls (n = 10; repeated-measures ANOVA, F = 45.71, p < 0.0001; Bonferroni's multiple comparison, p < 0.01). MB-treated R6/2 mice (n = 10) were not significantly different from nontransgenic littermates (n = 10; Bonferroni's multiple comparison: p > 0.05). C, MB treatment did not alter the clasping phenotype of the R6/2 mice (n = 10 in each group; Fisher's exact probability test, p > 0.05). D, Improvements in rotarod performance were also observed when treating R6/2 mice with MB (n = 10 in each group; ANOVA, F(3,36) = 12.49, p < 0.0001; Bonferroni's multiple comparison, *p < 0.05 at 7 weeks, p > 0.05 at 9 weeks). E, Treatment with MB resulted in improved performance (two-way ANOVA, treatment, F(3,36) = 4.64, p = 0.008; time, F(3,36) = 10.48, p = 0.003) on the pole-climbing task (n = 10 in each group). Bonferroni's multiple comparison, *p < 0.05, ****p < 0.0001. Error bars represent group means ± SEM.