Figure 3.
Behavioral phenotypes of CamDAT mice.
A
, DOX treatment was required for the survival of CamDAT mice.
B
, In the open field, locomotor activity of CamDAT mice was normal 1 week after DOX withdrawal. However, their locomotor activity sharply declined in the second week of DOX withdrawal (n = 4 per group, repeated-measures ANOVA, p < 0.001).
C
, Progressive body weight loss in CamDAT mice after DOX withdrawal (n = 6, repeated-measures ANOVA, p < 0.001 for group × week interaction).
D
, Four weeks after DOX withdrawal, CamDAT mice in their home cages consumed very little regular rodent chow (n = 5 per group, individually housed, unpaired t test, p < 0.001).
E
, Two weeks after DOX withdrawal, when provided with easily accessible chocolate flavored pellets (20 mg each) on the cage floor, CamDAT mice ate more than TetDAT mice (n = 6 per group, repeated-measures ANOVA, p < 0.001 for group × week interaction).